Mechanically ventilated patients are at high risk for complications. These risks include VAE, peptic ulcer disease (PUD), gastrointestinal bleeding, aspiration, venous thromboembolic events (VTE), and problems with secretion management. Evidence-based interventions can reduce the risk of these complications and reduce the occurrence of VAE. Implementing the ventilator bundle has shown to reduce VAE. The VAE prevention bundle includes: head of bed elevated 30 to 45 degrees, oral care with chlorhexidine 0.12%, peptic ulcer prophylaxis, deep vein thrombosis prophylaxis, and spontaneous waking trials and spontaneous breathing trials.